Abstract This study examines neurodegenerative diseases, primarily Alzheimer's disease, but also Parkinson's and Amyotrophic Lateral Sclerosis (ALS), within the framework of thermodynamics, physics, and systems theory, going beyond classical biomedical approaches. Neurodegenerative processes are interpreted as decreased energy efficiency, increased entropy production, and disruption of phase coherence between neuronal networks. In this context, Alzheimer's disease is modeled as an accelerated loss of order process in an out-of-equilibrium open biological system. The study also investigates music therapy, particularly through acoustic stimuli produced by breath-based instruments such as the ney (a type of flute). Music is defined as a low-energy but high-information-density external input that provides a regular time frequency structure without overloading the system with high energy. This approach is mathematically grounded using dissipative structure theory, the free energy principle, and oscillator synchronization models. It has been suggested that the acoustic spectral properties of the ney (a type of flute), its smooth harmonic structure, and its direct relationship with the rhythm of respiration may have a regulatory effect on the autonomic nervous system and brain networks. EEG, HRV, and clinical observations reported in the literature have been evaluated in a manner consistent with the developed theoretical model. Consequently, this study positions music therapy not as a causal treatment method, but as a complementary physical interaction that slows the rate of entropy increase, supports phase harmony, and increases system stability in neurodegenerative diseases. The presented model aims to establish the music-neurology relationship on a scientific and mathematical basis by offering an interdisciplinary framework. The positive effects of music on human health have been known since ancient times. In healing centers, patients were treated using the sounds of various instruments and the sound of water. Today, in many parts of the world and in our country, music is accepted and applied as a supportive method, both therapeutic and preventive, in intensive care units, inpatient wards, and outpatient treatment processes. Its more widespread use should be encouraged to ensure its effectiveness. While it's possible to say that live music performed by doctors and healthcare professionals in intensive care units and inpatient wards has a stronger effect on these patients, music played through other methods also proves effective. In outpatient settings and treatment processes, where a preventative effect is expected, live music or recorded music can have similar effects. In this regard, Turkish music should be primarily considered and evaluated due to its timbre characteristics, wide range, and rich content. [1-88
Emin Taner ELMAS (Fri,) studied this question.