What question did this study set out to answer?

To assess how mutation rates in melanoma driver genes influence prognosis in superficial spreading melanoma (SSM) and nodular melanoma (NM).

February 9, 2026Experimental Hematology and Oncology0 citationsOpen Access

Mutation rates in main tumour driver genes predict prognosis in patients with superficial spreading or nodular primary melanoma: results from the CARAMEL study by the Italian Melanoma Intergroup (IMI)

MSMaria Cristina SiniInstitute of Genetic and Biomedical Research EPErica PiccoliCentro di Riferimento Oncologico SSSara SimiUniversity of Florence

Key Points

To assess how mutation rates in melanoma driver genes influence prognosis in superficial spreading melanoma (SSM) and nodular melanoma (NM).
Evaluated mutational status of melanoma-driver genes.
Analyzed a series of SSMs and NMs from various Italian geographical areas.
Compared mutation rates between the two melanoma histotypes.
Increased numbers of mutated melanoma-driver genes were observed in both SSM and NM.
No distinct mutational pattern was found for SSM and NM lesions.
Higher mutation rates were significantly linked to shorter progression-free survival and poorer overall survival.

Abstract

Superficial spreading melanoma (SSM) and nodular melanoma (NM) are the two histotypes that account for most cutaneous primary melanomas. We evaluated the mutational status for the genes underlying melanomagenesis among a series of SSMs and NMs from different Italian geographical areas. An increased number of mutated melanoma-driver genes was found to occur in both histological subtypes, with no specific mutational pattern distinctive for SSM and NM lesions, being significantly associated to shorter progression-free survival and poorer overall survival.

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