Androgenetic alopecia (AGA) or pattern hair loss is a non-scarring hair condition defined by gradually reduced, miniaturized hair follicles. It is a multifactorial disorder primarily triggered by dysregulation of the hair cycle due to alterations between the crosstalk of numerous cell subpopulations. To provide a focus on existing and novel management options, preceded by a short overview of the current knowledge about AGA. A group of international experts in AGA analysed 85 literature sources about AGA (retrieved from PubMed and Google Scholar and published between 2000 and 2025) and discuss current and novel treatment options. Recent research evidenced that targeting the hair follicle and the surrounding tissue, rather than solely relying on solutions offered by minoxidil, finasteride, or other products, provides a safe and highly beneficial improvement of AGA. The authors underscore the significant scientific value and crucial role of advanced dermocosmetics with proven clinical efficacy in the long-term management of AGA, in addition to pharmacological active ingredients or other treatment options. These innovations offer compelling early intervention strategies, potentially delaying reliance on lifelong pharmaceutical regimens and optimizing the overall patient journey and quality of life. In addition to current treatment options of AGA, novel topical non-pharmacological therapeutic options are available, helping to safely and efficiently treat this multifactorial hair condition.
Piraccini et al. (Thu,) studied this question.
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