What question did this study set out to answer?

To explore the effects of co-milling on the cocrystal (BZQ)·(HQ) and its discoloration.

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February 11, 2026Open Access

Sublimation aides and abets co-milling and discoloration involving quinhydrone

Key Points

To explore the effects of co-milling on the cocrystal (BZQ)·(HQ) and its discoloration.
Co-milling (BZQ)·(HQ) with trans-bis(4-pyridyl)ethylene or 4-methoxyaniline.
Sublimation of BZQ is induced during the milling process.
Formation of targeted cocrystals (HQ)·(4,4′-BPE) and (HQ)·2(4-MA) observed.
Dark green color of (BZQ)·(HQ) discolors due to co-milling.
Successful formation of new cocrystals involving (HQ) and co-milling agents.

Abstract

We report an application of co-milling to the binary cocrystal (BZQ)·(HQ) or commonly known as quinhydrone. The co-milling is performed with either trans -bis(4-pyridyl)ethylene (4.4′-BPE) or 4-methoxyaniline (4-MA) . In both cases, the dark green color of (BZQ)·(HQ) in the sample undergoes discoloration with the co-milling. Sublimation of BZQ occurs with dismantling of (BZQ)·(HQ) to allow for formation of the targeted cocrystals (HQ)·(4,4′-BPE) and (HQ)·2(4-MA) .

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