What question did this study set out to answer?

The research aims to enhance the prediction of chemotherapy effectiveness in colorectal cancer using a novel nomogram.

February 11, 2026Open Access

Towards Precision Oncology: A Predictive Nomogram Incorporating DPD and MTHFR for CapeOX Neoadjuvant Chemotherapy in Colorectal Cancer

ETElvida Christy Imelda TahiyaUniversitas Islam Makassar RLRonald Erasio LusikooyUniversitas Islam Makassar IPIlhamjaya PattelongiUniversitas Islam Makassar

Key Points

The research aims to enhance the prediction of chemotherapy effectiveness in colorectal cancer using a novel nomogram.
Developed a predictive nomogram incorporating DPD and MTHFR biomarkers.
Evaluated the nomogram's effectiveness in estimating response to CapeOX neoadjuvant chemotherapy.
The nomogram significantly improved individualized response predictions.
Supports the idea of using biomarkers for tailored treatment strategies.

Abstract

A predictive nomogram that incorporated DPD and MTHFR has improved individualized estimation of CapeOX neoadjuvant chemotherapy response in CRC, supporting precision oncology strategies..

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