Higher BMI was associated with 29% lower plasma BNP levels in men and 23% lower in women when comparing the highest BMI group (BMI ≧ 25) to the lowest (BMI < 18.5).
Cross-Sectional (n=1,759)
No
Does higher BMI reduce plasma BNP levels in a general urban Japanese population?
In a general Japanese population, higher BMI and body fat mass are independently associated with lower plasma BNP levels, suggesting adiposity influences BNP clearance or production even in non-Western populations with lower average BMI.
Effect estimate: p < 0.001
Absolute Event Rate: 13% vs 23.4%
p-value: p=<0.001
The inverse association between plasma B-type natriuretic peptide (BNP) levels and body mass index (BMI) has been reported in Western populations. Here we analyzed the relationship between plasma BNP and obesity in a general urban Japanese population. We recruited 1,759 subjects without atrial fibrillation or history of ischemic heart disease aged 38-95 years (mean age +/- standard deviation 64.5 +/- 10.9 years, 56.1% women, mean BMI 22.8 +/- 3.1 kg/m(2)) from the participants in the Suita Study between August 2002 and December 2003. In multivariable regression analyses adjusted for age, systolic blood pressure, pulse rate, serum creatinine, left ventricular hypertrophy in ECG, the inverse relationships between BNP levels and BMI (kg/m(2)) was found in both sexes (both p<0.001). Multivariable-adjusted mean plasma BNP levels in the group of BMI<18.5, 18.5< or =BMI< 22, 22< or =BMI<25, and 25< or =BMI were 23.4, 17.9, 14.0 and 13.0 pg/mL, respectively (trend p<0.001). The negative association of body fat (percentage and mass), skin fold thickness, or waist circumference with BNP levels was observed the negative associations in both sexes (p<0.01). Among the obesity indices, body fat mass is most tightly associated with BNP. In conclusion, plasma BNP was inversely associated with obesity related markers such as body fat mass, skinfold thickness and waist circumferences after adjusted for relevant covariates in a Japanese population.
Sugisawa et al. (Fri,) conducted a cross-sectional in Obesity (n=1,759). BNP measurement vs. Various BMI categories was evaluated on Plasma BNP levels by BMI category (p < 0.001, p=<0.001). Higher BMI was associated with 29% lower plasma BNP levels in men and 23% lower in women when comparing the highest BMI group (BMI ≧ 25) to the lowest (BMI < 18.5).