What question did this study set out to answer?

To evaluate the impact of immediate lymphatic reconstruction on the incidence of postmastectomy lymphedema in breast cancer patients.

February 12, 2026

Immediate Lymphatic Reconstruction to Prevent Postmastectomy Lymphedema

Key Points

To evaluate the impact of immediate lymphatic reconstruction on the incidence of postmastectomy lymphedema in breast cancer patients.
Identified adult female breast cancer patients who underwent axillary lymph node dissection from 2007 to 2022.
Stratified patients by whether they received immediate lymphatic reconstruction.
Calculated adjusted odds of undergoing immediate lymphatic reconstruction and of developing postmastectomy lymphedema syndrome.
Only 1.3% of patients received immediate lymphatic reconstruction.
ILR was associated with a significant reduction in the odds of developing postmastectomy lymphedema syndrome (OR, 0.81; P = 0.02).
The frequency of ILR procedures has increased across regions from 2017 to 2022, especially in the Midwest and East.
Factors like more recent surgery year, younger age, and complete mastectomy were linked to higher odds of undergoing ILR (P ≤ 0.01).

Abstract

Background Lymphedema is a chronic disease characterized by swelling, inflammation, adipose deposition, and fibrosis. In the United States, lymphedema occurs most frequently as a sequela of oncologic lymphadenectomy. Axillary lymph node dissection (ALND) for breast cancer has been associated with a 5%–40% incidence of upper limb lymphedema. In immediate lymphatic reconstruction (ILR), surgeons perform lymphovenous anastomosis (LVA) with ALND to prevent the development of future lymphedema. Although early evidence supports a protective effect of ILR, there have been few large-scale studies on the topic. We leveraged a large claims database to better characterize the outcomes of ILR and national trends related to its adoption. Methods Adult female patients with breast cancer who underwent axillary lymph node dissection (ALND) between 2007 and 2022 were identified within the Merative MarketScan Research Databases and stratified according to whether they underwent ILR. Adjusted odds of undergoing ILR, both overall and regionally, and of experiencing postmastectomy lymphedema syndrome (PMLS) were calculated. Results Of all patients undergoing mastectomy and ALND, 1.3% received ILR. ILR was associated with decreased odds of developing PMLS (OR, 0.81; P = 0.02). The frequency of ILR procedures increased in all regions between 2017 and 2022, most dramatically in the Midwest and East US. More recent surgery year, younger age, complete mastectomy, and delayed ALND elevated the odds of undergoing ILR ( P ≤ 0.01). Conclusions The popularity of ILR has grown rapidly since 2017, with significant regional variability. Patients with breast cancer who undergo ILR at the time of ALND are significantly less likely to develop lymphedema.

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