Abstract An intact intranasal trigeminal function is crucial for chemosensory and somatosensory perception, environmental irritation detection, and triggering protective reflexes. Accurately assessing intranasal trigeminal function is thus essential. Since transient receptor potential (TRP) channels' activation mediates this function, their expression levels in the nasal mucosa may serve as potential indicators. The present study examined the relationship between intranasal trigeminal sensitivity, assessed via the lateralization task, and the messenger RNA (mRNA) expression levels of TRP channels using quantitative polymerase chain reaction (qPCR) in healthy individuals. The results indicated that individuals with lower lateralization scores exhibited significantly reduced TRPA1 mRNA expression levels, suggesting that TRPA1 density may influence behavioral responses to trigeminal stimulation. The findings provide promising evidence linking nasal TRPA1 expression to psychophysical measures, supporting the potential of nasal swabs as a simple, non‐invasive, biologically objective tool for assessing intranasal trigeminal function.
Joshi et al. (Thu,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: