Lost in translation: absence of KIAA1324/ELAPOR1 protein in pathological TDP-43-affected neurons in ALS/FTD

Key Points

• The research investigates the relationship between KIAA1324 protein levels and TDP-43 function in ALS and FTD.
• Analyzed post-mortem brain tissue for KIAA1324 mRNA and protein levels
• Investigated the relationship between KIAA1324 and TDP-43 in pathological conditions
• Identified the absence of KIAA1324 in neurons affected by TDP-43
• Found an inverse relationship between KIAA1324 mRNA levels and TDP-43 function
• Reported near complete absence of KIAA1324 protein in TDP-43 affected neurons
• Highlighted KIAA1324 as a potential therapeutic target downstream of TDP-43 in ALS/FTD