Recent Advances in the Synthesis of Lentiginosine and Its Epimers

Key Points

• The review aims to summarize the advancements in the synthesis of lentiginosine and its synthetic enantiomer.
• Reviewed literature on lentiginosine synthesis from 2006 to 2025.
• Analyzed methods to produce (+) and (−) lentiginosine.
• Explored the bioactivities associated with both enantiomers.
• (+)-Lentiginosine and (−)-lentiginosine demonstrate significant antitumor activity.
• Both enantiomers show potential in treating HIV and modulating immune responses.
• Recent synthesis techniques enhance the efficiency of producing these compounds.