Nanopore sequencing reveals ribosomal RNA modification changes in human cells experiencing oxidative or inflammatory stress

Key Points

• The study aims to investigate how oxidative and inflammatory stress affect ribosomal RNA modifications in human cells.
• Used nanopore sequencing technology to analyze ribosomal RNA.
• Applied modification-aware models from Dorado v5.2.0.
• Focused on human cellular responses to oxidative and inflammatory stress.
• Identified specific modifications in ribosomal RNA under stress conditions.
• Demonstrated altered modification patterns tied to oxidative and inflammatory influences.