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A lower-intensity, venetoclax-containing protocol is effective in adults with newly diagnosed mixed-phenotype acute leukemia | Synapse
February 14, 2026
Open Access
A lower-intensity, venetoclax-containing protocol is effective in adults with newly diagnosed mixed-phenotype acute leukemia
YZ
Ying Zhang
YF
Yi Fan
Soochow University
MX
Mimi Xu
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Key Points
The central aim is to assess the effectiveness of a lower-intensity protocol with venetoclax in treating mixed-phenotype acute leukemia in adults.
Designed a treatment protocol involving venetoclax for newly diagnosed patients.
Included adult participants diagnosed with mixed-phenotype acute leukemia.
Evaluated the effectiveness based on clinical outcomes.
The lower-intensity protocol showed promising clinical effectiveness.
Patients exhibited positive response rates to treatment.
Reduction in adverse effects compared to more intensive treatments.
Abstract
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Zhang et al. (Thu,) studied this question.
synapsesocial.com/papers/699010df2ccff479cfe57232
https://doi.org/https://doi.org/10.3324/haematol.2025.300161