This study aimed to identify the clinical characteristics, risk factors, and prognostic determinants of intracranial hemorrhage (ICH) in adult patients with acute leukemia (AL). We conducted a retrospective analysis of 3751 AL patients (aged ≥14 years) treated at our institution between 2010 and 2024. Independent risk factors for ICH included AL subtype, platelet count (PLT) 9/L, leukocytosis (WBC >100 × 109/L), elevated lactate dehydrogenase (LDH >245 IU/L), and prolonged prothrombin time (PT ≥3 s). The median overall survival (OS) in the ICH group was markedly shorter than in the NICH group (1.0 vs. 38.0 months, p 100 × 109/L), thrombocytopenia (PLT 9/L), APTT prolongation ≥10 s, and increased D-dimer (DDI) level (≥9 μg/mL) were independent risk factors for ICH, while increased DDI level (≥9 μg/mL) was associated with poor prognosis. These findings emphasize the importance of early risk stratification and targeted interventions to reduce the risk of ICH.
Li et al. (Wed,) studied this question.