What does this research mean for the field?

Orexin-1 receptor antagonism reduces food intake and weight gain in high-fat diet-fed mice, suggesting a role for orexin signaling in obesity-related satiety impairment. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore how orexin signaling affects satiety sensing in obesity.

February 16, 2026Journal of the Canadian Association of GastroenterologyOpen Access

Poster Session I - A90 INVESTIGATING THE ROLE OF OREXIN SIGNALING IN IMPAIRED SATIETY SENSING IN OBESITY.

View Full Paper

Ask AI

Bookmark

Authors

ODO I DiPaolo ACA Chakraborty SSS Sachdev

Discussion

Member takes

Overview

Finds orexin signaling reduction improves satiety in high-fat diet mice, implying treatment potential for obesity.

Key Points

This research aims to explore how orexin signaling affects satiety sensing in obesity.
Male and female C57BL/6 mice were fed high-fat or low-fat diets for 5 weeks.
Supernatants from fecal and jejunal contents were prepared for neuron experiments.
Naïve nodose ganglia neurons were exposed to supernatants, followed by excitability measurement.
HFD and LFD mice received daily intraperitoneal injections of an orexin-1 receptor antagonist.
NG neurons from HFD mice exhibited 73% higher rheobase than those from LFD mice.
Neurons treated with HFD supernatants demonstrated 50% greater rheobase than those with LFD supernatants.
HFD mice treated with the antagonist showed a 55% reduction in daily food intake.
Administering the antagonist led to an 8% decrease in body weight gain in HFD mice.

Cite This Study

DiPaolo et al. (2026) studied this question.

synapsesocial.com/papers/6992b4919b75e639e9b09848 https://doi.org/10.1093/jcag/gwaf042.090

View Full Paper

Ask AI

Bookmark

February 16, 2026Journal of the Canadian Association of GastroenterologyOpen Access

Poster Session I - A90 INVESTIGATING THE ROLE OF OREXIN SIGNALING IN IMPAIRED SATIETY SENSING IN OBESITY.

View Full Paper

Ask AI

Bookmark

Authors

ODO I DiPaolo ACA Chakraborty SSS Sachdev

Discussion

Member takes

Overview

Finds orexin signaling reduction improves satiety in high-fat diet mice, implying treatment potential for obesity.

Key Points

This research aims to explore how orexin signaling affects satiety sensing in obesity.
Male and female C57BL/6 mice were fed high-fat or low-fat diets for 5 weeks.
Supernatants from fecal and jejunal contents were prepared for neuron experiments.
Naïve nodose ganglia neurons were exposed to supernatants, followed by excitability measurement.
HFD and LFD mice received daily intraperitoneal injections of an orexin-1 receptor antagonist.
NG neurons from HFD mice exhibited 73% higher rheobase than those from LFD mice.
Neurons treated with HFD supernatants demonstrated 50% greater rheobase than those with LFD supernatants.
HFD mice treated with the antagonist showed a 55% reduction in daily food intake.
Administering the antagonist led to an 8% decrease in body weight gain in HFD mice.

Cite This Study

DiPaolo et al. (2026) studied this question.

synapsesocial.com/papers/6992b4919b75e639e9b09848 https://doi.org/10.1093/jcag/gwaf042.090

View Full Paper

Ask AI

Bookmark