What question did this study set out to answer?

The research aims to explore the continuous production of acetazolamide and p-aminobenzoic acid cocrystal using cooling cocrystallization.

February 19, 2026

Cooling cocrystallization of acetazolamide & p -aminobenzoic acid in continuous slug flow crystallizer

NNNeelesh NandanIndian Institute of Technology Patna ARAmit RajBirla Institute of Technology, Mesra AGAnimesh GhoshBirla Institute of Technology, Mesra

Key Points

The research aims to explore the continuous production of acetazolamide and p-aminobenzoic acid cocrystal using cooling cocrystallization.
Utilized a tubular slug flow crystallizer for continuous processing.
Mimicked batch cooling crystallization conditions.
Operated under a specific ratio of 1:1 for acetazolamide and p-aminobenzoic acid.
Successfully produced the 1:1 cocrystal of acetazolamide and p-aminobenzoic acid continuously.
Demonstrated effective crystallization dynamics within the slug flow system.

Abstract

Continuous production of the 1 : 1 acetazolamide (ACZ) : p -aminobenzoic acid (PABA) cocrystal was achieved via cooling cocrystallization in a tubular slug flow crystallizer, under conditions mimicking batch cooling crystallization.

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