Accessing Diverse Phosphorylated 2-Aryl Pyridines: A Strategic Protocol from Pd-PEPPSI to Palladium Acetate Catalysis

Key Points

• This research aims to evaluate the catalytic performance of Pd–PEPPSI complexes in cross-coupling reactions.
• Synthesis of Pd–PEPPSI complexes
• Conducting sequential Suzuki–Miyaura reactions
• Performing oxidative C–P cross-coupling reactions
• Evaluating catalytic performance under various conditions
• Pd–PEPPSI complexes demonstrated effective catalysis in C–C and C–P coupling reactions
• Higher yields observed in developed methodologies compared to traditional approaches
• Sequential reactions achieved substantial product diversity