Abstract Background In low- and middle-income countries (LMICs), fragmented diagnostic pathways often result in delayed breast cancer diagnosis and treatment. Patients are typically referred across departments (surgery, radiology, pathology), leading to multiple visits and potential loss to follow-up. The One-Stop Breast Clinic (OSBC) model, which integrates clinical evaluation, imaging, and biopsy into a single coordinated visit, aims to streamline this process. We present real-world data from a high-volume OSBC in South India to evaluate its diagnostic performance and workflow efficiency. Objective To assess the feasibility, diagnostic accuracy, and operational efficiency of the OSBC model in a private healthcare setting in India. MethodsThis retrospective audit included all female patients seen at Chennai Breast Centre from January 1 to December 31, 2024. Data were collected on patient demographics, imaging origin and quality, need for repeat evaluations, biopsy results, and diagnostic timelines. New symptomatic patients and follow-up visits were analyzed separately. Key outcome measures included the rate of repeat imaging/biopsy, time to biopsy, and time to treatment planning. ResultsAmong 12,156 patients, 2,777 were new symptomatic cases; 9,379 were follow-ups. New patients ranged in age from 12–93 years (mean: 47.5); Final diagnosis (new patients): Benign: 2,126 (76.5%), Malignant: 627 (22.6%)- Imaging origin: 1,158 (41.7%) had primary imaging at CBC; 1,619 (58.3%) presented with external scans- Repeat imaging required: 1,450 (52.2%), including 550 mammograms and 935 ultrasounds- Biopsies performed: 674 US-guided core biopsies, 2 punch, 8 stereotactic- MRI additionally performed in 70 patientsOf the 495 patients biopsied after repeat imaging, 384 had not been previously advised biopsy externally, suggesting significant diagnostic upgrades. Among 479 patients with prior external biopsies, 120 required a repeat biopsy; of these, 75 (62.5%) were malignant and 45 (37.5%) benign. This highlights a potential for missed malignancies with suboptimal external evaluations and emphasizes the critical need for quality-controlled, structured diagnostic workflows like the OSBC model. Workflow Efficiency Median time from patient entry to completion of history, clinical exam, imaging, and biopsy was 125 minutes. Biopsy reports were available within 72 hours. Unlike multispecialty hospitals that require multiple visits for triple assessment, the OSBC model completed this in a single session. Citation Format: D. Shankarraman, G. Sivaramalingam, N. Govindarajan, S. Radhakrishna. Bridging Diagnostic Gaps in LMICs- Real-World Functionality of a One-Stop Breast Centre in South India abstract. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS2-02-13.
Shankarraman et al. (Tue,) studied this question.