ABSTRACT Introduction The disturbances of circadian genes are implicated in the pathophysiology of bipolar disorder (BD). This bibliometric analysis aims to explore global trends and hotspots in research on circadian genes and BD. Design A bibliometric analysis. Methods A systematic search was carried out on the Web of Science Core Collection (WoSCC) database to collect publications regarding circadian genes and BD. Subsequently, bibliometric analysis and visualization utilized VOSviewer (V 1.6.20), CiteSpace (V 6.3.R1), and the R package “Bibliometrix” (V 4.3.3). Results The 400 articles involved 2405 authors from 1649 institutions, citing 18,840 sources in 166 journals. The number of publications has been consistently rising, with a 9.88% annual growth rate. The USA, Italy, and China dominated with the most articles. The most cited articles focused on the genetics of circadian disorders. The top institutions were the University of California system, the University of California, San Diego, and Université Paris. High‐impact authors included McClung Colleen A., McCarthy Michael J., and Benedetti Francesco. The top journals by H‐index were Chronobiology International , Journal of Affective Disorders , and American Journal of Medical Genetics . The keyword co‐occurrence analysis revealed focus on “depression,” “neurons,” “light therapy,” “genome wide association,” and “lithium.” The burst keywords highlighted the latest trends, including “sleep” and “brain,” with consistent emphasis on “risk.” Conclusion: This bibliometric analysis provides insights into the global trends and hotspots of research on circadian genes and BD. The hotspots are on symptoms, genetic associations, and treatment in BD, with frontiers exploring sleep patterns, brain functions, and risk factors.
Ruan et al. (Sun,) studied this question.