The aim of this study was to prepare matrix tablets of ethinyl estradiol and levonorgestrel using different polymers for controlled drug release in PCOS treatment. The tablets were prepared by the direct compression method. Compatibility studies showed no interaction between the drugs and excipients.The prepared tablets were evaluated for physical properties and drug content, and all results were within acceptable limits. In-vitro dissolution studies showed that the polymers helped in sustained release of the drugs for a longer time. The optimized formulation provided controlled release and good tablet quality.This study concludes that matrix tablets are a simple and effective approach for sustained delivery of ethinyl estradiol and levonorgestrel, which may improve patient compliance in PCOS management.
Shaik Reshma Kousar*, Shaik Nafisa, D. Mounika, D. Mythri, C. Sowmya, D. Sirisha (Mon,) studied this question.