What question did this study set out to answer?

To highlight the challenges in diagnosing primary signet-ring carcinoma of the eyelid and its treatment options.

February 22, 2026

Primary signet-ring carcinoma of the eyelid: a case report

Key Points

To highlight the challenges in diagnosing primary signet-ring carcinoma of the eyelid and its treatment options.
Case report of a rare eyelid tumor
Review of clinicopathological characteristics
Assessment of previous case reports regarding treatment options
Signet-ring carcinoma often misdiagnosed due to non-specific features
Limited treatment guidelines exist due to few reported cases
Prognosis remains unclear without extensive studies

Abstract

Introduction: Primary signet-ring carcinoma of the eyelid (PSCE) is a rare aggressive adnexal tumour with less than 60 reported cases. 1 PSCE is commonly misdiagnosed given its rarity and non-specific clinical and radiological features. A thorough clinicopathological work up is required to exclude metastatic signet-ring cell carcinoma before making a definitive diagnosis. The prognosis and optimal treatment are unclear given the limited number of cases reported. 2

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