Vitamin K-dependent coagulopathy following cephazolin therapy: diagnostic and causal insights from a post-operative MSSA endocarditis case

Key Points

• This report examines vitamin K-dependent coagulopathy related to cephazolin therapy in endocarditis cases.
• Case report of a patient with MSSA endocarditis
• Assessment of coagulopathy linked to cephalosporin use
• Evaluation of vitamin K production and metabolism
• Identified coagulopathy as a rare side effect of cephazolin
• Confirmed impaired γ-carboxylation of vitamin K-dependent factors
• Highlighted the relationship between antibiotic therapy and vitamin K levels