The aim is to identify how different factors affect the benefits of early antibiotic therapy in ICU patients with sepsis without shock.
Analyzed data from ICU patients with sepsis without shock.
Examined treatment effects based on age, comorbidities (CCI, APS III), and liver dysfunction.
Utilized multiple methods to assess the impact of time-to-antibiotics.
Older patients and those with higher CCI and APS III scores benefit more from faster antibiotic treatment.
Patients with acute liver dysfunction showed increased positive outcomes with shorter time-to-antibiotics.
Abstract
Among ICU patients with sepsis without shock, those who are older, have higher CCI or APS III, or acute liver dysfunction are more likely to benefit from shorter time-to-antibiotics.