ENPP3 drives ccRCC progression by cGAMP hydrolysis and STING–IFN suppression

Key Points

• The research aims to investigate the role of ENPP3 in ccRCC progression and its potential as a therapeutic target.
• Analyzed the function of ENPP3 in ccRCC cells under hypoxic conditions.
• Examined the effects of ENPP3 inhibition on STING-dependent immune responses.
• Investigated cGAMP hydrolysis as a mechanism of ENPP3's action.
• Inhibition of ENPP3 reactivated STING pathways, enhancing anti-tumor immunity.
• cGAMP levels increased following ENPP3 inhibition, indicating a disruption in its hydrolysis.
• Hypoxia enhances ENPP3 expression, correlating with ccRCC progression.