Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates

Key Points

• To investigate the impact of glioblastoma on perivascular diffusivity and glymphatic function.
• Analysis of DTI-ALPS index in glioblastoma-affected brain hemispheres.
• Assessment of volume and cellularity metrics in relation to DTI-ALPS measurements.
• Integration of radio-pathomic and histopathologic data.
• Correlation analysis between the DTI-ALPS index and other metrics.
• Significant reduction in DTI-ALPS index in tumor-affected hemispheres.
• Inverse correlation established between DTI-ALPS index and volume metrics.
• Inverse correlation between DTI-ALPS index and cellularity metrics.