Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway

Key Points

• The study investigates how Annexin A1 influences islet stellate cell activation through triglyceride metabolism.
• Examined the role of Annexin A1 in activating islet stellate cells.
• Analyzed triglyceride catabolism pathways involving PPARα.
• Evaluated the relationship between Annexin A1 and islet fibrosis.
• Annexin A1 significantly promotes islet stellate cell activation.
• Enhancement of triglyceride catabolism was linked to the PPARα pathway.
• Potential therapeutic implications for treating islet fibrosis were identified.