Lactylation-related genes contribute to neurological injury and prognosis of acute ischemic stroke based on transcriptome and single-cell sequencing analysis | Synapse
February 25, 2026Open Access
Lactylation-related genes contribute to neurological injury and prognosis of acute ischemic stroke based on transcriptome and single-cell sequencing analysis
Key Points
To explore the relationship between lactylation-related genes and neurological outcomes in acute ischemic stroke patients.
Conducted transcriptome analysis to assess lactylation-related genes (LRGs) in acute ischemic stroke (AIS) patients.
Utilized single-cell sequencing to examine cellular responses and inflammatory status in the brain tissue of AIS patients.
Analyzed correlations between LRG expression levels and neurological deficit severity.
Found significant correlations between LRGs and the severity of neurological deficits in AIS patients.
Identified LRGs as potential prognostic biomarkers for assessing the prognosis of AIS, correlating with inflammatory markers.
Abstract
Our findings reveal significant correlations between LRGs in AIS patients and both neurological deficit severity and inflammatory status, highlighting LRGs as potential prognostic biomarkers for AIS.