What question did this study set out to answer?

The research aims to investigate the antimicrobial properties of indene-based compounds and their mechanisms.

February 25, 2026RSC Advances2 citationsOpen Access

Indene and indole-based compounds as potential antimicrobial agents: synthesis, activity, docking studies and ADME analysis

VLVilma Lovrinčević MRMonika Šabić Runjavec NBNikica Baričević

Key Points

The research aims to investigate the antimicrobial properties of indene-based compounds and their mechanisms.
Synthesis of various indene derivatives
Evaluation of antimicrobial activities against multiple microbial species
In silico molecular docking studies to analyze inhibitory mechanisms
ADME analysis to assess absorption, distribution, metabolism, and excretion properties
Certain indene derivatives show significant antimicrobial activity against selected microorganisms
Molecular docking indicates plausible mechanisms of inhibition in targeted microbes
ADME analysis suggests favorable properties for potential therapeutic use

Abstract

Various indene derivatives are presented and their antimicrobial activities against different microbial species are evaluated. To elucidate the plausible inhibitory mechanism in silico molecular docking study was performed for selected molecules.

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Cite This Study

Lovrinčević et al. (Thu,) studied this question.

synapsesocial.com/papers/699e9152f5123be5ed04ec60 https://doi.org/https://doi.org/10.1039/d5ra08239k

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