What question did this study set out to answer?

Examine gray matter asymmetry and structural differences in perinatally HIV-exposed adolescents compared to peers.

February 25, 2026

Gray matter asymmetry alterations in perinatally HIV-exposed adolescents: evidence from structural neuroimaging

JLJinfeng LvWuhan University LFLing FengWuhan University LGLingling GaoYuncheng University

Key Points

Examine gray matter asymmetry and structural differences in perinatally HIV-exposed adolescents compared to peers.
Utilized structural neuroimaging to assess brain structure and asymmetry.
Compared adolescents living with HIV (ALHIV) and HIV-exposed uninfected (HEU) individuals to typically developing (TD) peers.
Analyzed localized brain alterations associated with infection status.
ALHIV and HEU exhibited significant deviations in gray matter asymmetry compared to TD peers.
Perinatal HIV exposure resulted in additional localized structural changes in the brain.

Abstract

Perinatal HIV exposure is associated with atypical GM asymmetry and structural organization in adolescence. Both ALHIV and HEU exhibit deviations from TD peers, with infection status contributing additional localized alterations.

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