February 25, 2026The Anatolian Journal of Cardiology0 citationsOpen Access
The Impact of Intravenous Agitated Saline Contrast Echocardiography on Subclinical Neuronal Injury Determined By Neuron-Specific Enolase
Key Points
- To evaluate if intravenous agitated saline contrast echocardiography (SCE) induces silent neuronal injury as measured by neuron-specific enolase (NSE).
- Conducted a safety assessment of SCE using neuron-specific enolase as a biomarker.
- Included patients without underlying neuronal susceptibility.
- Compared NSE levels before and after SCE.
- Findings suggest that SCE does not cause silent neuronal injury in the studied population.
- NSE levels remained stable, indicating no significant neuronal damage.
Abstract
This study is the first to evaluate whether SCE causes silent neuronal injury. It is suggested that when evaluated with NSE, the SCE method is safe and does not cause silent neuronal injury in patients without underlying neuronal susceptibility.