Abstract Colorectal cancer is a major global public health concern since it is the second most prevalent cause of cancer-related mortality worldwide. Early rectal neoplasia requires treatment strategies that ensure oncologic safety while preserving rectal function and quality of life. Transanal minimally invasive surgery (TAMIS) has traditionally served as a standard local excision technique, whereas endoscopic submucosal dissection (ESD) has emerged as a less invasive alternative capable of achieving en bloc resection of large, non-pedunculated rectal lesions. In this news and views, we will discuss the recently published DSETAMIS trial, which compares ESD and TAMIS for early rectal cancer.
Kar et al. (Mon,) studied this question.