Formulation of metered-dose inhalers containing beclomethasone dipropionate using quality by design approach.

Key Points

• To develop a robust formulation of metered-dose inhalers for beclomethasone dipropionate using a quality by design approach.
• Utilized the quality by design (QbD) framework for formulation development.
• Created a design space for metered-dose inhalers containing beclomethasone dipropionate.
• Optimized the formulation to enhance performance.
• The optimized formulation matched the performance of the reference inhaler product.
• Supports the potential for more affordable beclomethasone therapies.