Efficacy of nicotiflorin in ameliorating septic acute kidney injury: the role of PINK1/parkin in mitochondrial restoration and oxidative stress reduction.

Key Points

• Evaluate the efficacy of nicotiflorin in treating septic acute kidney injury (AKI) through mitochondrial restoration.
• Examined the effects of nicotiflorin on septic acute kidney injury
• Analyzed mitochondrial function and oxidative stress levels
• Investigated the role of the PINK1/Parkin pathway in treatment outcomes.
• Nicotiflorin attenuated mitochondrial dysfunction in septic AKI.
• Oxidative stress levels were significantly reduced by nicotiflorin treatment.
• The PINK1/Parkin signaling pathway was implicated in the therapeutic effects.