Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at 7T.

Key Points

• This research aims to quantify brain deuterium metabolism using 7T imaging in healthy individuals and glioblastoma patients.
• Utilized 7T MRI for brain deuterium metabolic imaging (DMI)
• Compared metabolic profiles between glioblastoma patients and healthy volunteers
• Analyzed lactate (Lac) and glutamate/glutamine (Glx) levels
• Glioblastoma tumors exhibited increased Lac levels compared to normal brain.
• Reduced Glx labeling was observed in glioblastoma patients.
• Inter-patient metabolic heterogeneity suggests different glioblastoma subtypes.