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February 27, 2026Open Access

Correlation between HER2 gene copy number and immunohistochemistry categories in HER2-negative breast cancer: diagnostic utility for differentiating HER2-null, ultralow, and low tumors

Key Points

The research aims to explore the relationship between HER2 gene copy number and immunohistochemistry (IHC) categories in HER2-negative breast cancer.
Analyzed HER2 gene copy number and immunohistochemistry categories in breast cancer samples.
Compared results between HER2-low, HER2-null, and low tumors.
Statistical analysis conducted to evaluate correlations.
HER2 gene copy number showed a positive correlation with protein expression as per IHC categories.
HER2-low tumors had statistically higher gene copy numbers than HER2-null tumors.
Significant overlap in copy number ranges limits effective distinction between HER2-low and HER2-null tumors.

Abstract

HER2 gene copy number was positively correlated with protein expression as reflected by IHC categories. Although HER2 gene copy number was statistically higher in HER2-low than in HER2-null tumors, the substantial overlap in copy number ranges likely limits its utility in distinguishing HER2-low from HER2- null BCs.

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Cite This Study

Kim et al. (Wed,) studied this question.

synapsesocial.com/papers/69a134b8ed1d949a99abe27d https://doi.org/https://doi.org/10.4132/jptm.2025.11.07

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