Biosynthetic gene clusters (BCG) of secondary metabolite biosynthesis in Pseudogymnoascus spp. strains were analyzed using the antiSMASH program (fungal version). It was shown for the first time that the genomes of Pseudogymnoascus fungi contain several dozen BCG of secondary metabolite biosynthesis. Of these, approximately 30% were gene clusters of known metabolites with a similarity of 9–100%. When cultivating 8 Pseudogymnoascus spp. strains in a mineral medium, 13 metabolites were detected. Five strains had 3–4 compounds in the spectrum, and three strains biosynthesized the siderophore desferritriacetylflusigen. It was shown that the secondary metabolites synthesized by Pseudogymnoascus spp. strains possess potential biological activity. The highest antibacterial, antifungal, phytotoxic and entomotoxic activity was demonstrated by secondary metabolites of strains VKM F–4513 and F–4517 isolated from Arctic permafrost deposits.
T.V. Antipova (Wed,) studied this question.