In the United States, heroin initiation that is self-reported to have occurred after 2000 differs in magnitude and character from that from the late 1970s through mid-1990s. Changes began before dates commonly associated with restrictions on opioid prescribing. This appears consistent with a view that "trading down" from prescription opioid misuse to consumption of illegally manufactured opioids did not only occur after implementation of policies to reduce opioid prescribing.
Caulkins et al. (Tue,) studied this question.
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