What does this research mean for the field?

Higher levels of lipoprotein(a) are associated with an increased risk of atherosclerotic cardiovascular disease in both linear and nonlinear manners. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to clarify how lipoprotein(a) levels are associated with the risk of atherosclerotic cardiovascular disease, exploring both linear and nonlinear relationships.

February 28, 2026Open Access

Linear and Nonlinear Associations Between Lipoprotein(a) and the Risks of Atherosclerotic Cardiovascular Disease

Key Points

This research aims to clarify how lipoprotein(a) levels are associated with the risk of atherosclerotic cardiovascular disease, exploring both linear and nonlinear relationships.
Used observational studies to analyze Lp(a) levels.
Employed Mendelian randomization to assess causal relationships.
Examined both linear and nonlinear associations with atherosclerotic cardiovascular disease risk.
Identified significant associations between elevated Lp(a) levels and increased ASCVD risk.
Demonstrated that the association trend may not be strictly linear, indicating potential complexities in the relationship.

Abstract

Background: Lipoprotein(a) Lp(a) is a recognized risk factor for atherosclerotic cardiovascular disease (ASCVD), but the shape and potential nonlinearity of its association remain uncertain. We assessed the linear and nonlinear associations between Lp(a) levels and ASCVD risk using observational and Mendelian randomization (MR) approaches.

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Linear and Nonlinear Associations Between Lipoprotein(a) and the Risks of Atherosclerotic Cardiovascular Disease

Key Points

Abstract

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