What does this research mean for the field?

1,2,3-triazole nucleoside analogues with an N-acetyl-D-glucosamine residue exhibit moderate cytotoxicity against various human cancer cell lines. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to synthesize 1,2,3-triazole nucleoside analogues and evaluate their cytotoxic effects against cancer cells.

February 28, 2026

1,2,3-Triazole Nucleoside Analogues with a N-Acetyl-D-glucosamine Residue. Synthesis and Cytotoxic Activity

Key Points

This research aims to synthesize 1,2,3-triazole nucleoside analogues and evaluate their cytotoxic effects against cancer cells.
Copper-catalyzed azide-alkyne cycloaddition used for synthesis.
3,4,6-tri-O-acetyl-2-deoxy-2-acetamido-β-D-glucopyranosyl azide reacted with N-propargyl derivatives.
In vitro cytotoxicity evaluated against various human cancer cell lines.
The synthesized compounds showed moderate cytotoxicity against several cancer cell lines.
Cell lines tested include M-HeLa, MCF-7, PANC-1, PC-3, T 98G, A 549, and HuTu 80.

Abstract

A series of 1,2,3-triazole nucleoside analogues containing an N-acetyl-D-glucosamine residue was synthesized via copper-catalyzed azide-alkyne cycloaddition of 3,4,6-tri-O-acetyl-2-deoxy-2-acetamido-β-D-glucopyranosyl azide with N-propargyl derivatives of phenothiazine, carbazole, isatin, phthalimide, and imidazolin-2-one. The synthesized compounds demonstrated moderate in vitro cytotoxicity against human cancer cell lines M-HeLa, MCF-7, PANC-1, PC-3, T 98G, A 549, and HuTu 80.

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1,2,3-Triazole Nucleoside Analogues with a N-Acetyl-D-glucosamine Residue. Synthesis and Cytotoxic Activity

Key Points

Abstract

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