A series of 1,2,3-triazole nucleoside analogues containing an N-acetyl-D-glucosamine residue was synthesized via copper-catalyzed azide-alkyne cycloaddition of 3,4,6-tri-O-acetyl-2-deoxy-2-acetamido-β-D-glucopyranosyl azide with N-propargyl derivatives of phenothiazine, carbazole, isatin, phthalimide, and imidazolin-2-one. The synthesized compounds demonstrated moderate in vitro cytotoxicity against human cancer cell lines M-HeLa, MCF-7, PANC-1, PC-3, T 98G, A 549, and HuTu 80.
Aznagulov et al. (Thu,) studied this question.