What question did this study set out to answer?

This research aims to explore how circular RNAs (circRNAs) are regulated by ionizing radiation in triple-negative breast cancer cells.

February 28, 2026Open Access

Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation

Key Points

This research aims to explore how circular RNAs (circRNAs) are regulated by ionizing radiation in triple-negative breast cancer cells.
Analyzed circRNA expression patterns in different cell lines exposed to ionizing radiation.
Assessed time- and dose-dependent changes in circRNA levels.
Performed pathway enrichment analysis to identify potential applications of circRNAs.
Identified distinct circRNA expression patterns specific to cell lines under radiation.
Highlighted circRNAs as potential biomarkers for radiation sensitivity.
Proposed circRNAs as therapeutic targets to improve treatment outcomes in TNBC.

Abstract

The cell line-specific radiation-dependent circRNA expression patterns reflect the molecular diversity of TNBC, and pathway enrichments indicate the potential applications of these circRNAs as radiation sensitivity biomarkers and therapeutic targets to improve TNBC treatment efficacy.

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Cite This Study

Papatsirou et al. (Thu,) studied this question.

synapsesocial.com/papers/69a287010a974eb0d3c0264f https://doi.org/https://doi.org/10.1007/s12094-026-04280-1

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