Engineered Covalent Organic Frameworks-based Nanosystem for Strengthening Pyroptosis-Mediated Tumor Immunotherapy

Key Points

• The central aim is to develop a nanosystem that enhances tumor immunotherapy by triggering pyroptosis in tumors.
• Developing covalent organic frameworks chemistry for nanosystem creation
• Assessing the impact on tumor immunosuppressive microenvironment
• Evaluating immune response modifications through pyroptosis induction
• Enhanced immune response observed in transformed hot tumors
• Significant reduction in tumor size and growth
• Induction of pyroptosis led to altered immune cell infiltration