Anti-Gingivitis and Anti-Osteoclastogenesis Effects of Ethanol Extract from Hippophae rhamnoides L. Fruits in IL-1β-Induced Human Gingival Fibroblasts and RANKL-Induced RAW 264.7 Macrophages

Key Points

• To investigate the effects of Hippophae rhamnoides ethanol extract on gingivitis and osteoclast formation.
• Used IL-1β-induced human gingival fibroblasts to assess gingivitis effects.
• Utilized RANKL-induced RAW 264.7 macrophages to evaluate osteoclastogenesis.
• Conducted assays to measure the extract's effects on cell activity and inflammatory markers.
• Hippophae rhamnoides extract significantly reduced IL-1β-induced inflammation in gingival fibroblasts.
• The extract decreased osteoclast formation in RANKL-induced RAW 264.7 macrophages.
• Bioactive compounds in the extract showed potential for improving oral health.