Nitrogen blowing DµSPE of sunitinib, imatinib, and dasatinib using LDH/MIL-101(Cr)-NO2 composite prior to HPLC-PDA.

Key Points

• The research aims to develop a method for efficiently extracting anti-cancer drugs from biological samples using a novel composite filter.
• Utilized nitrogen blowing for extraction
• Employed a LDH/MIL-101(Cr)-NO2 composite as sorbent
• Conducted extraction prior to HPLC-PDA analysis
• Focused on minimizing solvent and sorbent use
• Achieved high performance in detecting sunitinib, imatinib, and dasatinib
• Reduced extraction time compared to traditional methods
• Showed effective use of minimal amounts of materials