Aim: This study investigates the interplay between biological, genetic, and socioeconomic determinants of mental health, focusing on their combined impact on adult mental health outcomes in the United Kingdom. It explores the roles of genetic predisposition, biological aging, social determinants, and adverse childhood experiences in shaping mental health conditions such as schizophrenia, depression, and anxiety. Methodology: A systematic review was conducted using a Population, Intervention, Outcome framework. After applying strict inclusion and exclusion criteria, nine studies were selected. These studies were critically appraised using the Critical Appraisal Skills Programme Checklist and analysed for key themes. Results: Mental health outcomes are shaped by a complex interplay of genetic susceptibility, biological aging, socioeconomic inequalities, adverse childhood experiences, and social connectivity. Schizophrenia, depression, and cognitive decline are closely linked to genetic predisposition and aging processes, while structural disadvantages, early life trauma, and social isolation significantly heighten vulnerability, particularly among marginalised populations. Strengths and Limitations: This study employs a rigorous systematic review methodology with a comprehensive search strategy and a targeted adult demography in the United Kingdom, ensuring relevance and reliability; however, limitations include potential publication bias, a restricted time frame, subjectivity in study selection, and challenges in translating findings into clinical practice. Recommendations: A multidisciplinary approach integrating public mental health awareness, socioeconomic interventions, research innovation, and improved access to mental health services is essential for reducing disparities, enhancing early detection, and ensuring holistic, inclusive mental health care across diverse populations. Conclusion: Mental health outcomes result from a complex interplay of genetic predisposition, biological processes, and socioeconomic conditions. A holistic, interdisciplinary approach integrating healthcare, policy, and community support is essential for reducing disparities and improving mental health outcomes across the United Kingdom.
Ugochi Agbo (Wed,) studied this question.