A disrupted balance between energy production and consumption in contemporary humans is largely accounted for by lack of physical activity. It is widely acknowledged that lack of physical activity can cause lifestyle-related diseases, while exercise represents not only a preventive/therapeutic measure against these diseases but a viable approach to ensuring healthy longevity. It has become clear, however, that, of all patients with lifestyle-related diseases, those implementing exercise account only for a small proportion, one important reason being that it remains difficult not only to set a clear goal for exercise therapy but to continue it, given the contemporary lifestyle.
Masato Iwabu (Thu,) studied this question.