What does this research mean for the field?

The haplotype-resolved genome assembly of Centella asiatica reveals allelic imbalance and a history of whole-genome duplication that contributes to triterpenoid biosynthesis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The research aims to explore the genome evolution and factors influencing triterpene accumulation in Centella asiatica.

March 2, 2026Open Access

A haplotype-resolved genome assembly for Centella asiatica provides insights into its genome evolution and ursane-type triterpene accumulation

Key Points

The research aims to explore the genome evolution and factors influencing triterpene accumulation in Centella asiatica.
Assembled a haplotype-resolved genome for Centella asiatica.
Analyzed allelic imbalance between haplotypes.
Constructed a metabolic regulatory network for triterpenoid saponins.
Identified a whole-genome duplication event followed by chromosomal fusion.
Found that triterpenoid biosynthesis was linked to gene duplication.
Developed insights into the genetic basis for triterpenoid diversity.

Abstract

Centella asiatica is a medicinal plant containing various ursane-type saponins that serve as a model system for studying triterpenoid accumulation. We assembled a haplotype-resolved genome for C. asiatica , and it showed allelic imbalance between haplotypes. The genome underwent one whole-genome duplication event followed by chromosomal fusion resulting in the current karyotype. We also constructed the metabolic regulatory network of triterpenoid saponins and found that triterpenoid biosynthesis was accompanied by gene duplication. These findings may assist in mining genes for the metabolism of C. asiatica and improving the understanding of the genetic basis for the diversity of triterpenoid biosynthesis

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