Objectives: Acne vulgaris is a common inflammatory skin disorder influenced by factors such as sebum production, microbial colonization, and the use of comedogenic topical products, which can promote microcomedone formation. Considering the potential role of facial cleansers in triggering or worsening acne, this study aims to evaluate the skin compatibility and non- comedogenic profile of Venusia acne facewash under occluded skin conditions compared to control products, to assess its dermatological safety for acne-prone skin. Material and Methods: This was a prospective, randomized, double-blinded, positive- and negative-controlled, within-subject, site-randomized study. Healthy male and female subjects with follicular orifices on the upper back region were enrolled in this study. The test product (Venusia acne facewash), positive control (coconut oil), and negative control (glycerine) were applied occlusively on the three marked sites. Follicular biopsy by the cyanoacrylate method was performed for each site at baseline and at the end of the study. The product was applied and occluded using a patch after 2 h of the biopsy on alternate days over a period of approximately 1 month (24 visits). Microcomedones were graded using a four-point grading scale: 0 = non-comedogenic; 1 = presence of small microcomedones; 2 = moderately sized microcomedones; and 3 = large, globoid microcomedones present throughout the entire field. Results: A total of 30 subjects were enrolled, of whom 29 completed the study and were included in the data analysis. The majority of the subjects enrolled were female (58.6%). The mean comedogenic grade for the coconut oil (positive control) and glycerine (negative control) was 2.07 and 0.76, respectively. The method was validated by the significant difference ( P = 0.001) between the positive and negative controls. The mean comedogenic grade in Venusia acne facewash was 1.00, significantly ( P = 0.001) less than the positive control. One subject reported an adverse event (AE) not related to the study product and was discontinued from the study. No serious AEs were reported in any of the study subjects. Conclusion: Venusia acne facewash is a non-comedogenic and well-tolerated formulation specifically designed for acne-prone skin. It offers cleansing without exacerbating acne or inducing dryness and irritation. Venusia acne facewash can be used as an everyday, gentle cleanser to promote clearer, healthier, and balanced skin in individuals with acne.
Gala et al. (Sat,) studied this question.