ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease | Synapse
March 3, 2026Open Access
ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease
Key Points
This research aims to explore the role of ACSS2-mediated lysine crotonylation in reducing senescence and improving the effectiveness of adipose-derived stem cells in treating inflammatory bowel disease.
Identified the epigenetic pathway involving ACSS2, Kcr, and H3K9cr.
Analyzed the impact of Kcr modulation on the senescence of adipose-derived stem cells.
Evaluated the therapeutic efficacy of enhanced ADSCs in inflammatory bowel disease models.
Demonstrated that ACSS2-mediated lysine crotonylation reduces senescence in adipose-derived stem cells.
Showed that modulation of Kcr enhances the therapeutic effects of these cells in inflammatory bowel disease.
Abstract
Our findings reveal an epigenetic pathway (ACSS2-Kcr-H3K9cr) regulating ADSCs senescence and propose Kcr modulation as a novel strategy to enhance ADSC-based therapy for IBD.