Introduction: Allergic asthma is triggered by allergens and is commonly associated with elevated IgE levels. Histamine plays a pivotal role in its pathogenesis; however, the therapeutic role of antihistamines remains controversial. Since current treatments primarily provide symptomatic relief, this review evaluates the current status of antihistamines in asthma management, with a focus on pharmacological advances, natural therapies, and novel heterocyclic compounds. Method: A comprehensive literature search was systematically conducted across major databases, including PubMed, ScienceDirect, Scopus, and Web of Science. Studies evaluating the pharmacological potential of antihistamines, herbal compounds, and novel synthetic derivatives were included. Exclusion criteria encompassed studies unrelated to asthma or antihistamines, non-English publications, and editorials or conference abstracts lacking primary data. Results: Second- and third-generation antihistamines effectively alleviate symptoms of allergic asthma and can reduce corticosteroid use. Combining antihistamines with leukotriene receptor antagonists has been shown to further enhance treatment outcomes. Emerging evidence also suggests that heterocyclic compounds and plant-derived phytochemicals may serve as promising antihistamines and bronchodilators, although their clinical application remains limited. Discussion: Modern antihistamines provide added value as supportive agents in asthma management, particularly for allergic subtypes. Their improved pharmacological profiles reduce sedation and enhance patient compliance. The synergistic use of antihistamines with corticosteroids or leukotriene inhibitors exemplifies a shift toward multimodal therapy, while novel compounds continue to broaden therapeutic possibilities. Conclusion: Antihistamines are increasingly recognized as valuable adjuvants in asthma management. Although asthma remains incurable, advanced antihistamines and natural phytochemicals provide effective symptom relief. Continued research into novel compounds and integrated therapeutic strategies holds promise for improved disease control and enhanced quality of life.
Verma et al. (Wed,) studied this question.