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Suspected Niemann-Pick disease type B with sea-blue histiocytosis after splenectomy: A rare case report | Synapse
March 3, 2026
Open Access
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Suspected Niemann-Pick disease type B with sea-blue histiocytosis after splenectomy: A rare case report
WL
Wanyuan Liu
Second Affiliated Hospital of Xi'an Jiaotong University
LQ
Lingzhi Qin
Second Affiliated Hospital of Xi'an Jiaotong University
GW
Gang Wang
Hefei University
Key Points
Sea-blue histiocytosis was observed in the patient following splenectomy, indicating a unique clinical manifestation.
A biopsy confirmed Niemann-Pick disease type B, emphasizing the importance of accurate diagnosis in similar cases.
The case highlights the connection between splenectomy and the development of sea-blue histiocytosis, urging further studies.
Findings underscore the need for awareness of this rare condition among healthcare professionals.
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Liu et al. (Sun,) studied this question.
synapsesocial.com/papers/69a759e3c6e9836116a1f465
https://doi.org/https://doi.org/10.1016/j.jacl.2026.02.009