USP15 promotes proliferation, migration, and apoptosis resistance of pulmonary arterial smooth muscle cells by targeting MDM2

Key Points

• Proliferation and migration rates increase in pulmonary arterial smooth muscle cells due to USP15.
• Cells showed enhanced resistance to apoptosis as indicated by significant increases in survival rates.
• Assessment using cellular assays demonstrates USP15's direct effect on MDM2 modulation in these cells.
• These findings highlight the need for further exploration of USP15 as a therapeutic target in pulmonary vascular diseases.